Plasmalogen Related Papers


  • Orally administered plasmalogens alleviate negative mood states and enhance mentalconcentration: a randomized, double-blind, placebo-controlled trial.M.Fujino, et al.Front CellDev Biol 10:894734, 2022
  • Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells againstthe Target Cells.S. Hossain, et al.J Immunol 209:310-325, 2022
  • Plasmalogens, the vinyl ether-linkedglycerophospholipids, enhance learning and memory byregulating brain-derived neurotrophic factor. S.Hossain, et al.Front Cell Dev Biol10:828282, 2022


  • Plasmalogenattenuates LPS-induced ICAM-1 expression in endothelial cell line.R.Kanda, et al.J Osaka Dent Univ 5: 179-185, 2021


  • Therapeutic efficacy of plasmalogens for Alzheimer’s disease, Mild Cognitive Impairment andParkinson’s disease in conjunction with a new hypothesis for the etiology of Alzheimer’s disease.T. Fujino, etal. Peroxisome Biology. Lizard G (ed). Adv Exp Med Biol1299:195-212, 2020
  • Biological Functions of Plasmalogens.S. Hossain, et al. Peroxisome Biology. Lizard G (ed). AdvExp Med Biol 1299:171-193,2020
  • Improvement ofblood plasmalogens and clinicalsymptoms in Parkinson’sdisease by oraladministration of ether phospholipids: a preliminary report.S.Mawatari, et al. Parkinsons Dis2020:2671070, 2020
  • Identification of plasmalogens in Bifidobacterium longum, but not in Bifidobacterium animalis.S.Mawatari, et al. J Sci Rep 10: 427, 2020
  • Distinctfunctions of Acyl/Alkyldihydroxyacetonephosphate reductase in peroxisomes andendoplasmic reticulum.M.Honsho, et al.FrontCell Dev Biol 8:855, 2020


  • Effects ofplasmalogen on patients withmoderate-to-severe Alzheimer’sdisease and bloodplasmalogen changes: a multi-center, open-label studyT. Fujino, et al. J Alzheimers DisParkinsonism9: 474, 2019
  • PUFA-plasmalogens attenuate the LPS-induced nitric oxide production by inhibitingthe NF-kB,p38 MAPK and JNKpathways in microglial cells.M.Youssef,et al. Neuroscience 397: 18–30, 2019
  • Plasmalogens inhibit endocytosis of toll-like receptor 4 to attenuate the inflammatory signalin microglialcells.F. Ali, et al. Mol Neurobiol 56: 3404-3419,2019


  • Effects ofplasmalogen on patients with mild cognitive impairment: a randomized, placebo-controlled trialin Japan.T.Fujino,et al. J Alzheimers Dis Parkinsonism8: 419, 2018
  • Plasma anderythrocyte membrane plasmalogens in patients withcoronary heart diseasesundergoing percutaneous intervention.T. Arita, et al. Cardiology and Angiology: An International

          Journal 7: 1-11, 2018

  • Scallop-derived plasmalogens attenuate the activation of PKCd associated with the braininflammation.S. Sejimo, et al.Biochem Biophys Res Commun503: 837-842, 2018
  • Oral ingestion of plasmalogens can attenuate the LPS-induced memory loss and microglialactivation.MS. Hossain, et al.Biochem Biophys Res Commun496: 1033-1039, 2018
  • Enzymatic measurement of etherphospholipids in human plasma after hydrolysis of plasmawith phospholipase A1.S.Mawatari,et al.Pract Lab Med 10:44-51, 2018


  • Efficacy andblood plasmalogen changes by oral administration of plasmalogen in patients withmildAlzheimer’sdiseaseand mild cognitive impairment: a multicenter, randomized, double-blind, placebo-controlled trial.T. Fujino, et al.EBioMedicine 17: 199-205, 2017
  • Plasma anderythrocyte membrane plasmalogen diminished in severe atheroscleroticpatients undergoingendovascular therapy.H.Noda,etal.Membrane42: 242-249, 2017
  • Reduction ofether-type glycerophospholipids, plasmalogens, by NF-kBsignal leading tomicroglial activation.MS.Hossain,et al.J Neurosci 37:4074-4092, 2017


  • Measurement of ether phospholipids in human plasma with HPLC-ELSD and LC/ESI-MS afterhydrolysis of plasma with phospholipase A1.S.Mawatari,et al. Lipids51:997-1006, 2016
  • NeuronalorphanG-protein coupled receptor proteins mediateplasmalogens-induced activationof ERK and Aktsignaling.MS.Hossain,et al.PLoS One11:e0150846, 2016


  • Bioactivelipids safeguard our brain from various challenges.TKatafuchiet al.Fukuoka IgakuZasshi106:293-301, 2015
  • Plasmalogensrescue neuronal cell death through an activationof AKT and ERKsurvivalsignaling.MS.Hossain,et al.PLoS One 8:e83508, 2013
  • Changes inphospholipid composition of erythrocyte membrane inAlzheimer’sdisease.S. Oma,et al. Dement Geriatr Cogn DisordExtra 2: 298-303, 2012
  • Dietary plasmalogen increases erythrocyte membrane plasmalogen in rats.S.Mawatari, et al.Lipids Health Dis11:161, 2012
  • Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-inducedneuroinflammation in adult mice.M. Ifuku, et al. J Neuroinflammation 9: 197, 2012
  • Effects of plasmalogens on systemic lipopolysaccharide-induced glial activationand β-amyloidaccumulation in adult mice.T. Katafuchi,et al.Ann N Y Acad Sci 1262:85-92,2012
  • Simultaneouspreparation of purified plasmalogens and sphingomyelin in human erythrocyteswith phospholipase A1fromAspergillus orizae.S.Mawatari,et al.Biosci Biotechnol Biochem 73:2621-2625,2009
  • Separation of intact plasmalogens and all other phospholipids by a single run of high-performance liquid chromatography.S.Mawatari,et al.Anal Biochem 370: 54-59, 2007